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Reference Substances


L-4-Hydroxyisoleucine is a non-proteinogenic amino acid naturally found in fenugreek seeds (Trigonella foenum-graecum), known for its insulinotropic and glucose-regulating properties. With the CAS number 6001-78-8 and a purity of ≥98% HPLC, L-4-Hydroxyisoleucine has garnered significant interest for its potential therapeutic applications in managing diabetes, enhancing insulin sensitivity, and supporting metabolic health.

Product Details

  • Product Name: L-4-Hydroxyisoleucine
  • CAS Number: 6001-78-8
  • Purity: ≥98% HPLC
  • Molecular Formula: C6H13NO3
  • Molecular Weight: 147.17 g/mol
  • Appearance: White to off-white crystalline powder
  • Solubility: Soluble in water, slightly soluble in ethanol, insoluble in ether
  • Storage: Store at -20°C, protected from light and moisture

Features & Benefits

  • Insulinotropic Activity: Enhances insulin secretion, beneficial for managing blood sugar levels in diabetes.
  • Improves Insulin Sensitivity: Supports glucose uptake by cells, improving insulin sensitivity and metabolic health.
  • Natural Origin: Extracted from fenugreek seeds, offering a holistic approach to diabetes management and metabolic support.
  • Research Potential: A valuable compound for scientific research into diabetes, metabolic syndrome, and insulin resistance mechanisms.


  • Pharmaceutical Research: Investigated for its potential in developing natural treatments for diabetes and insulin resistance.
  • Nutraceuticals: Utilized in dietary supplements aimed at supporting blood sugar regulation and metabolic health.
  • Functional Foods: Incorporated into food products designed to enhance metabolic wellness and support diabetes management.
  • Biotechnological Studies: Employed in research studies exploring mechanisms of action and therapeutic applications.

Safety & Compliance

  • Produced under strict quality control standards to ensure high purity and safety.
  • Each batch is accompanied by a comprehensive Certificate of Analysis (CoA) for quality assurance.
  • Recommended for use by healthcare professionals and researchers familiar with the handling and safety protocols of bioactive compounds.


  • Available in 20mg and 1g quantities to support a range of applications from research and development to commercial formulations.
  • Packaged in air-tight containers to preserve stability and ensure product integrity during storage and handling.









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