Best Herbal Extracts

Botanical Ingredient

Silybum Marianum Extract

Derived from the milk thistle plant, Silybum marianum extract offered by Stanford Chemical Company (SCC) is an herbal remedy featuring silybin as its primary active ingredient. It is renowned for its remarkable liver-protective properties. Trust SAM’s Silybum marianum extract for a natural approach to liver health and vitality.

SKU HE3119 Categories ,

Silybum Marianum Extract Description

Derived from the milk thistle plant, Silybum marianum extract is an herbal remedy renowned for its liver-protective properties. The primary active component, silybin, plays a pivotal role in stabilizing liver cell membranes, enhancing liver function, and exerting an enzyme-lowering effect without causing rebound.

Silymarin, a key element in the extract, contributes to the stability and integrity of liver cell membranes. It facilitates ultrastructural recovery in hepatocytes, promotes normal hepatocyte division and growth, and improves RNA and protein synthesis. Furthermore, it enhances the reticuloendothelial system’s phagocytic ability, boosts macrophage activity, and accelerates virus elimination.

Silybin’s multifaceted effects include promoting fat transfer, antioxidation, and preventing excessive fat oxidation and infiltration. This combats liver steatosis, enhances liver metabolism, fortifies detoxification, and reduces damage to liver cells. Overall, silybin emerges as a potent protector of normal liver cells and a promoter of damaged cell membrane recovery.

Silybum Marianum Extract Specifications

Product Name Silybum Marianum Extract
CAS Registry Number 22888-70-6
Molecular Formula C25H22O10
Molecular Weight 482.436
Purity 30%, 95%, 98% Silybin by HPLC
Appearance Yellow powder
Active ingredients Silybin (CAS: 22888-70-6 )

Silydianin (CAS: 29782-68-1)

Silychristin (CAS: 33889-69-9 )

Package 1kg-25kg
Shelf life 2 years
Functions Protect liver, anti-oxidation, prevent the liver from the damage of drugs, alcohol, and heavy metal, anti-aging of skin

Silybum Marianum Extract Applications

  • Cosmetic Anti-Aging Agent:
    • Utilized as a cosmetic ingredient for its anti-aging properties, Silybum Marianum Extract contributes to skincare formulations aimed at promoting youthful and radiant skin.
  • Liver Protective Component in Pharmaceuticals:
    • Incorporated into pharmaceuticals, Silybum Marianum Extract acts as a key element in drugs designed to shield the liver from environmental stressors, alcohol, chemical toxicants, and other potential damages.
  • Atherosclerosis and Radiation Prevention:
    • Recognized for its preventive capabilities, Silybum Marianum Extract is employed to help ward off conditions like atherosclerosis and mitigate the impact of radiation exposure.

Silybum Marianum Extract Packaging

1 kg/ aluminum foil bag, 25 kg/drum, or as required.

Our Silybum Marianum Extract is clearly tagged and labeled externally to ensure efficient identification and quality control. Great care is taken to avoid any damage which might be caused during storage or transportation.

Silybum Marianum Extract Safety Tips

Handling of Silymarin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.


  • 1. Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy.
    Xie Y, Lu Y, Qi J, Li X, Zhang X, Han J, Jin S, Yuan H, Wu W.Int J Pharm. 2012 Dec 16. doi:pii: S0378-5173(12)01061-7.  10.1016/j.ijpharm.2012.12.007. [Epub ahead of print]
  • 2. Meta-analysis: silymarin and its combination therapy for the treatment of chronic hepatitis B.
    Wei F, Liu SK, Liu XY, Li ZJ, Li B, Zhou YL, Zhang HY, Li YW.Eur J Clin Microbiol Infect Dis. 2012 Dec 18. [Epub ahead of print]
  • 3. [Silibinin and its hepatoprotective action from the perspective of a toxicologist].
    Kostek H, Szponar J, Tchórz M, Majewska M, Lewandowska-Stanek H.Przegl Lek. 2012;69(8):541-3. Polish.
  • 4. Herbal Supplement Ameliorates Cardiac Hypertrophy in Rats with CCl(4)-Induced Liver Cirrhosis.
    Li PC, Chiu YW, Lin YM, Day CH, Hwang GY, Pai P, Tsai FJ, Tsai CH, Kuo YC, Chang HC, Liu JY, Huang CY.Evid Based Complement Alternat Med. 2012;2012:139045. doi: 10.1155/2012/139045. Epub 2012 Nov 6.
  • 5. Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice.
    Yamaura K, Nakayama N, Shimada M, Ueno K.Pharmacognosy Res. 2012 Oct;4(4):234-6. doi: 10.4103/0974-8490.102274.
  • 6. Hepatoprotective and antiviral functions of silymarin components in HCV infection.
    Polyak SJ, Ferenci P, Pawlotsky JM.Hepatology. 2012 Dec 5. doi: 10.1002/hep.26179. [Epub ahead of print] No abstract available.
  • 7. Effects of single or repeated silymarin administration on pharmacokinetics of risperidone and its major metabolite, 9-hydroxyrisperidone in rats.
    Lee KS, Chae SW, Park JH, Park JH, Choi JM, Rhie SJ, Lee HJ.Xenobiotica. 2012 Dec 20. [Epub ahead of print]
  • 8. Protective effect of silymarin during coronary artery bypass grafting surgery.
    Altaei T.Exp Clin Cardiol. 2012 Winter;17(1):34-8.
  • 9. Evaluation of the Hepatoprotective Effects of Lantadene A,  a Pentacyclic Triterpenoid of Lantana Plants against Acetaminophen-induced Liver Damage.
    Grace-Lynn C, Chen Y, Latha LY, Kanwar JR, Jothy SL, Vijayarathna S, Sasidharan S.Molecules. 2012 Nov 23;17(12):13937-47. doi: 10.3390/molecules171213937.
  • 10. Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage.
    Jain PK, Kharya M, Gajbhiye A.Drug Dev Ind Pharm. 2012 Nov 20. [Epub ahead of print]
  • 11. Effect of Topical Application of Silymarin (Silybum marianum) on Excision Wound Healing in Albino Rats.
    Sharifi R, Rastegar H, Kamalinejad M, Dehpour AR, Tavangar SM, Paknejad M, Mehrabani Natanzi M, Ghannadian N, Akbari M, Pasalar P.Acta Med Iran. 2012 Sep;50(9):583-8.
  • 12. Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
    Ahmad I, Shukla S, Kumar A, Singh BK, Kumar V, Chauhan AK, Singh D, Pandey HP, Singh C.Chem Biol Interact. 2012 Nov 16;201(1-3):9-18. doi: 10.1016/j.cbi.2012.10.027. [Epub ahead of print]
  • 13. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L.
    Saeed N, Khan MR, Shabbir M.BMC Complement Altern Med. 2012 Nov 16;12:221. doi: 10.1186/1472-6882-12-221.
  • 14. Effect of Smilax zeylanica roots and rhizomes in paracetamol induced hepatotoxicity.
    Murali A, Ashok P, Madhavan V.J Complement Integr Med. 2012 Nov 9;9(1). doi:pii: /j/jcim.2012.9.issue-1/1553-3840.1639/1553-3840.1639.xml.  10.1515/1553-3840.1639.
  • 15. Treatment with silymarin for hepatitis C virus.
    Ferenci P.JAMA. 2012 Nov 14;308(18):1856-7; author reply 1857. doi: 10.1001/jama.2012.13741. No abstract available.
  • 16. Protective effect of Mollugo nudicaulis Lam. on acute liver injury induced by perchloroethylene in experimental rats.
    Rajamanikandan S, Sindhu T, Durgapriya D, Sophia D, Ragavendran P, Gopalakrishnan VK.Asian Pac J Trop Med. 2012 Nov;5(11):862-7. doi: 10.1016/S1995-7645(12)60161-8.
  • 17. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats.
    Mihailovi? V, Mihailovi? M, Uskokovi? A, Arambaši? J, Miši? D, Stankovi? V, Katani? J, Mladenovi? M, Soluji? S, Mati? S.Food Chem Toxicol. 2012 Nov 9;52C:83-90. doi: 10.1016/j.fct.2012.10.034. [Epub ahead of print]
  • 18. Potential antioxidant properties and hepatoprotective effects of an aqueous extract formula derived from three Chinese medicinal herbs against CCl(4)-induced liver injury in rats.
    Yang CC, Fang JY, Hong TL, Wang TC, Zhou YE, Lin TC.Int Immunopharmacol. 2012 Nov 7. doi:pii: S1567-5769(12)00309-8.  10.1016/j.intimp.2012.10.017. [Epub ahead of print]
  • 19. Silymarin for diabetic nephropathy: the challenges of botanical product research.
    Meyers CM, Briggs JP.Am J Kidney Dis. 2012 Dec;60(6):887-9. doi: 10.1053/j.ajkd.2012.09.002. No abstract available.
  • 20. Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase.
    Xu HM, Chen Y, Xu J, Zhou Q.World J Gastroenterol. 2012 Nov 7;18(41):5972-8. doi: 10.3748/wjg.v18.i41.5972.


Product Name




Molecular Formula


Molecular Weight



98% HPLC


25 kg/drum


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