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Home » Products » Botanical Ingredient » 10-Hydroxycamptothecin

10-Hydroxycamptothecin

Chemical Structure of 10-Hydroxycamptothecin

10-Hydroxycamptothecin is extracted from Camptotheca acuminata. Stanford Chemicals has been providing quality 10-Hydroxycamptothecin and many other natural plant extract for over 15 years.

Product Name

10-Hydroxycamptothecin

CAS No.

19685-09-7

Molecular Formula

C20H16N2O5

Molecular Weight

364.35

Botanical Source

Camptotheca acuminata

Purity

98% HPLC

Appearance

Pale yellow powder

Package

25 kg/drum

Storage

Stored in cool & dry places, protected from direct sunlight and heat.

10-Hydroxycamptothecin Safety Tips

Handling of 10-Hydroxycamptothecin should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

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    Molecular Weight: 348.35
    Purity: 98% HPLC
    Package: 1kg; 5kg;10kg

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  • Mabimu Extract

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References
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    Qu JB, Shao HH, Jing GL, Huang F.Colloids Surf B Biointerfaces. 2013 Feb 1;102:37-44. doi: 10.1016/j.colsurfb.2012.08.004. Epub 2012 Aug 19.

  • 3. Enhanced in vitro antitumor efficacy and strong anti-cell-migration activity of a hydroxycamptothecin-encapsulated magnetic nanovehicle.

    Ding GB, Liu HY, Lv YY, Liu XF, Guo Y, Sun CK, Xu L.Chemistry. 2012 Oct 29;18(44):14037-46. doi: 10.1002/chem.201200765. Epub 2012 Sep 20.

  • 4. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs.

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  • 10. Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene.

    Hirose K, Kozu C, Yamashita K, Maruo E, Kitamura M, Hasegawa J, Omoda K, Murakami T, Maeda Y.Oncol Lett. 2012 Mar;3(3):694-698. Epub 2011 Dec 22.

  • 11. Induction and mechanism of apoptosis by hydroxycamptothecin in human Tenon's capsule fibroblasts.

    Tang W, Zhang Y, Qian C, Yuan Z, Du J.Invest Ophthalmol Vis Sci. 2012 Jul 24;53(8):4874-80. doi: 10.1167/iovs.11-8968. Print 2012 Aug.

  • 12. 7-Ethyl-10-hydroxycamptothecin proliposomes with a novel preparation method: optimized formulation, characterization and in-vivo evaluation.

    Wang S, Ye T, Yang B, Yi X, Yao H.Drug Dev Ind Pharm. 2012 May 15. [Epub ahead of print]

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  • 15. Preparation and in vitro evaluation of an ultrasound-triggered drug delivery system: 10-hydroxycamptothecin loaded PLA microbubbles.

    Hou Z, Li L, Zhan C, Zhu P, Chang D, Jiang Q, Ye S, Yang X, Li Y, Xie L, Zhang Q.Ultrasonics. 2012 Sep;52(7):836-41. doi: 10.1016/j.ultras.2011.10.009. Epub 2011 Dec 13.

  • 16. A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue.

    Zheng J, Guo H, Guo N, Ma W, Jing L, Zhang R, Dai Z, Yan X, Wang Y, Wang Z.Pharm Biol. 2012 Aug;50(8):954-61. doi: 10.3109/13880209.2011.654228. Epub 2012 Apr 10.

  • 17. MARVELD1 inhibited cell proliferation and enhance chemosensitivity via increasing expression of p53 and p16 in hepatocellular carcinoma.

    Yu Y, Zhang Y, Hu J, Zhang H, Wang S, Han F, Yue L, Qu Y, Zhang Y, Liang H, Nie H, Li Y.Cancer Sci. 2012 Apr;103(4):716-22. doi: 10.1111/j.1349-7006.2012.02220.x. Epub 2012 Mar 8.

  • 18. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation.

    Luo X, Xie C, Wang H, Liu C, Yan S, Li X.Int J Pharm. 2012 Apr 4;425(1-2):19-28. doi: 10.1016/j.ijpharm.2012.01.012. Epub 2012 Jan 14.

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    Sun HH, Zhang J, Zhang YZ, Yang LY, Yuan LL, Liu Y.Mol Biol Rep. 2012 May;39(5):5115-23. doi: 10.1007/s11033-011-1307-z. Epub 2011 Dec 9.

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