Best Herbal Extracts

Standard Herbal Extract

Tetrandrine Powder

Tetrandrine (CAS: 518-34-3), a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic, and antiallergenic effects.

CAS Number 518-34-3
Appearance White powder
Type Alkaloid
Source Stephania Tetrandra Root
Keywords Tetrandrine
Synonyms (1)-6,6’,7,12-Tetramethoxy-2,2’-dimethylberbaman

Tetrandrine (CAS: 518-34-3) Description

Tetrandrine (CAS: 518-34-3) is a bis-benzylisoquinoline alkaloid found in Stephania tetrandra and other Asian herbs, acting as a calcium channel blocker with anti-inflammatory, immunologic, and antiallergenic properties. It prevents mast cell degranulation and has quinidine-like effects against arrhythmias.

Notably, tetrandrine shows significant anti-tumor properties, enhancing tumor cell cytotoxicity, overcoming multidrug resistance, protecting normal tissues from radiation, and inhibiting angiogenesis. Its promising effects highlight its potential as a cancer treatment or an adjunct to conventional chemotherapy and radiotherapy.

Tetrandrine (CAS: 518-34-3) Specifications

Product Name Tetrandrine
CAS Registry Number 518-34-3
Molecular Formula C38H42N2O6
Molecular Weight 622.75
Assay ≥90%
Pubchem 73078

Tetrandrine (CAS: 518-34-3) Applications

– Source Plant: Stephania tetrandra from the Menispermaceae family is a major source of tetrandrine, a bisbenzylisoquinoline alkaloid.
– Traditional Use: Recognized in the Chinese Pharmacopoeia for its analgesic and diuretic properties, also used to treat hypertension, asthma, tuberculosis, dysentery, hyperglycemia, malaria, cancer, and fever.
– Calcium Channel Blocker: Acts as a calcium channel blocker with clinical trials confirming its efficacy in treating silicosis, hypertension, inflammation, and lung cancer without toxicity.
– Antimicrobial and Antiviral Activity: Proven effective against Mycobacterium tuberculosis, Candida albicans, Plasmodium falciparum, and the Ebola virus in recent studies.
– Mechanism of Action: Influences various signaling pathways including reactive oxygen species production, autophagic flux enhancement, reversal of multidrug resistance, activation of the caspase pathway, cell cycle arrest, and modification of calcium channels.



    There are no reviews yet.

    Be the first to review “Tetrandrine Powder”

    Your email address will not be published. Required fields are marked *