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Tetrandrine Powder

Tetrandrine (CAS: 518-34-3), a bis-benzylisoquinoline alkaloid, is a calcium channel blocker. It has anti-inflammatory, immunologic, and antiallergenic effects.

CAS Number 518-34-3
Appearance White powder
Type Alkaloid
Source Stephania Tetrandra Root
Keywords Tetrandrine
Synonyms (1)-6,6’,7,12-Tetramethoxy-2,2’-dimethylberbaman

Tetrandrine (CAS: 518-34-3) Description

Tetrandrine (CAS: 518-34-3) is a bis-benzylisoquinoline alkaloid found in Stephania tetrandra and other Asian herbs, acting as a calcium channel blocker with anti-inflammatory, immunologic, and antiallergenic properties. It prevents mast cell degranulation and has quinidine-like effects against arrhythmias.

Notably, tetrandrine shows significant anti-tumor properties, enhancing tumor cell cytotoxicity, overcoming multidrug resistance, protecting normal tissues from radiation, and inhibiting angiogenesis. Its promising effects highlight its potential as a cancer treatment or an adjunct to conventional chemotherapy and radiotherapy.

Tetrandrine (CAS: 518-34-3) Specifications

Product Name Tetrandrine
CAS Registry Number 518-34-3
Molecular Formula C38H42N2O6
Molecular Weight 622.75
Assay ≥90%
Pubchem 73078

Tetrandrine (CAS: 518-34-3) Applications

– Source Plant: Stephania tetrandra from the Menispermaceae family is a major source of tetrandrine, a bisbenzylisoquinoline alkaloid.
– Traditional Use: Recognized in the Chinese Pharmacopoeia for its analgesic and diuretic properties, also used to treat hypertension, asthma, tuberculosis, dysentery, hyperglycemia, malaria, cancer, and fever.
– Calcium Channel Blocker: Acts as a calcium channel blocker with clinical trials confirming its efficacy in treating silicosis, hypertension, inflammation, and lung cancer without toxicity.
– Antimicrobial and Antiviral Activity: Proven effective against Mycobacterium tuberculosis, Candida albicans, Plasmodium falciparum, and the Ebola virus in recent studies.
– Mechanism of Action: Influences various signaling pathways including reactive oxygen species production, autophagic flux enhancement, reversal of multidrug resistance, activation of the caspase pathway, cell cycle arrest, and modification of calcium channels.

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