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Hederagenin (CAS: 465-99-6)

Hederagenin (CAS: 465-99-6) is the aglycone part of numerous saponins found in Hedera helix (common ivy), the most prevalent of these being hederacoside C and alpha-hederin.

CAS Number 465-99-6
Appearance White crystalline powder
Type Triterpenoid
Source Natural Ivy Leaf
Keywords Hederagenin
Synonyms HG

Hederagenin (CAS: 465-99-6) Description

Hederagenin (CAS: 465-99-6) is a sapogenin found in Hedera helix (common ivy), particularly in saponins like hederacoside C and alpha-hederin. It’s also a key triterpenoid in Chenopodium quinoa, recognized by the EPA as a biopesticide component. Demonstrating antidepressant-like effects in rodent studies, Hederagenin is a plant-derived pentacyclic triterpenoid, akin to oleanolic acid, with roles as a plant metabolite and dihydroxy monocarboxylic acid.

Hederagenin (CAS: 465-99-6) Specifications

Product Name Hederagenin
CAS Registry Number 465-99-6
Molecular Formula C30H48O4
Molecular Weight 472.710 g/mol
Assay ≥97%
Solubility Methanol: 1 mg/mL

Hederagenin (CAS: 465-99-6) Applications

  • Anti-tumor Activity: Hederagenin demonstrates broad anti-tumor effects against various cancers including lung, colon, stomach, liver, ovarian, prostate, breast, and endometrial. It operates by modifying gene/protein expression, reducing tumor weight and altering the expression of several key genes and proteins related to cancer progression.
  • Anti-inflammatory Activity: Since the 1970s, Hederagenin has shown anti-inflammatory and anti-arthritic effects. In mouse models, it significantly reduced edema, showcasing its potential as an anti-inflammatory agent.
  • Anti-depressant Activity: Hederagenin enhances central monoamine signaling by inhibiting the reuptake of serotonin, norepinephrine, and dopamine, acting as a triple inhibitor of monoamine transporters. This contributes to its antidepressant effects.
  • Anti-neurodegenerative Activity: It activates autophagy, promoting the clearance of proteins associated with neurodegenerative diseases like Parkinson’s and Huntington’s, and has shown potential in improving motor deficits and cognitive functions in animal models.
  • Anti-hyperlipidemia Activity: In a rat model, Hederagenin reduced cholesterol, triglycerides, and improved liver function and blood viscosity, indicating its potential in treating hyperlipidemia.
  • Anti-leishmanial Activity: As a biopesticide, Hederagenin sodium salt has shown effectiveness against Leishmania strains in vitro, comparable to reference compounds, highlighting its potential as a leishmanicidal agent.



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