Standard Herbal Extract

Evodia Extract Safety Tips

Handling of Evodia Extract should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats.
  Zhang W, Fujikawa T, Mizuno K, Ishida T, Ooi K, Hirata T, Wada A.Am J Chin Med. 2012;40(4):735-52. doi: 10.1142/S0192415X12500553.
• 2. Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells.
  Kwon SH, Kim MJ, Ma SX, You IJ, Hwang JY, Oh JH, Kim SY, Kim HC, Lee SY, Jang CG.J Ethnopharmacol. 2012 Jul 13;142(2):337-45. doi: 10.1016/j.jep.2012.04.010. Epub 2012 May 14.
• 3. Screening, identification, and potential interaction of active compounds from Eucommia ulmodies leaves binding with bovine serum albumin.
  Zhang Y, Peng M, Liu L, Shi S, Peng S.J Agric Food Chem. 2012 Mar 28;60(12):3119-25. doi: 10.1021/jf205135w. Epub 2012 Mar 13.
• 4. A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension.
  Greenway F, Liu Z, Yu Y, Gupta A.Altern Med Rev. 2011 Dec;16(4):338-47.
• 5. Eucommia ulmoides bark protects against renal injury in cadmium-challenged rats.
  Liu E, Han L, Wang J, He W, Shang H, Gao X, Wang T.J Med Food. 2012 Mar;15(3):307-14. doi: 10.1089/jmf.2011.1756. Epub 2011 Dec 19.
• 6. Validation of a HPLC-tandem MS/MS method for pharmacokinetics study of (+)-pinoresinol-di-β-D-glucopyranoside from Eucommia ulmoides Oliv extract in rats’ plasma.
  Wang JL, Liu EW, Zhang Y, Wang T, Han LF, Gao XM.J Ethnopharmacol. 2012 Jan 31;139(2):337-42. doi: 10.1016/j.jep.2011.10.037. Epub 2011 Nov 22.
• 7. Facilitative effects of Eucommia ulmoides on fatty acid oxidation in hypertriglyceridaemic rats.
  Kobayashi Y, Hiroi T, Araki M, Hirokawa T, Miyazawa M, Aoki N, Kojima T, Ohsawa T.J Sci Food Agric. 2012 Jan 30;92(2):358-65. doi: 10.1002/jsfa.4586. Epub 2011 Aug 4.
• 8. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice.
  He K, Li X, Chen X, Ye X, Huang J, Jin Y, Li P, Deng Y, Jin Q, Shi Q, Shu H.J Ethnopharmacol. 2011 Oct 11;137(3):1135-42. doi: 10.1016/j.jep.2011.07.033. Epub 2011 Jul 20.
• 9. Effect of total glycosides from Eucommia ulmoides seed on bone microarchitecture in rats.
  Li Y, Wang MJ, Li S, Zhang YM, Zhao Y, Xie RM, Sun WJ.Phytother Res. 2011 Dec;25(12):1895-7. doi: 10.1002/ptr.3543. Epub 2011 Jun 14.
• 10. Anti-obesity compounds in green leaves of Eucommia ulmoides.
  Hirata T, Kobayashi T, Wada A, Ueda T, Fujikawa T, Miyashita H, Ikeda T, Tsukamoto S, Nohara T.Bioorg Med Chem Lett. 2011 Mar 15;21(6):1786-91. doi: 10.1016/j.bmcl.2011.01.060. Epub 2011 Jan 21.
• 11. Eucommia ulmoides Oliv. antagonizes H2O2-induced rat osteoblastic MC3T3-E1 apoptosis by inhibiting expressions of caspases 3, 6, 7, and 9.
  Lin J, Fan YJ, Mehl C, Zhu JJ, Chen H, Jin LY, Xu JH, Wang HM.J Zhejiang Univ Sci B. 2011 Jan;12(1):47-54. doi: 10.1631/jzus.B1000057.
• 12. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice.
  Kwon SH, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG.Neurosci Lett. 2011 Jan 3;487(1):123-7. doi: 10.1016/j.neulet.2010.10.042. Epub 2010 Oct 23.
• 13. Chronic administration of Eucommia leaf stimulates metabolic function of rats across several organs.
  Fujikawa T, Hirata T, Wada A, Kawamura N, Yamaguchi Y, Fujimura K, Ueda T, Yurugi Y, Soya H, Nishibe S.Br J Nutr. 2010 Dec;104(12):1868-77. doi: 10.1017/S0007114510002965. Epub 2010 Aug 9.
• 14. [Study on the quality standards of decoction pieces of salt Eucommia].
  Lv ZY, Di LQ, Zhao XL, Cai BC, Jin HZ.Zhong Yao Cai. 2010 Jan;33(1):30-3. Chinese.
• 15. Antioxidant properties of Du-zhong (Eucommia ulmoides Oliv.) extracts and their effects on color stability and lipid oxidation of raw pork patties.
  Xu Z, Tang M, Li Y, Liu F, Li X, Dai R.J Agric Food Chem. 2010 Jun 23;58(12):7289-96. doi: 10.1021/jf100304t.
• 16. Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats.
  Jin X, Amitani K, Zamami Y, Takatori S, Hobara N, Kawamura N, Hirata T, Wada A, Kitamura Y, Kawasaki H.J Ethnopharmacol. 2010 Apr 21;128(3):672-8. doi: 10.1016/j.jep.2010.02.019. Epub 2010 Feb 26.
• 17. Studies on a chlorogenic acid-producing endophytic fungi isolated from Eucommia ulmoides Oliver.
  Chen X, Sang X, Li S, Zhang S, Bai L.J Ind Microbiol Biotechnol. 2010 May;37(5):447-54. doi: 10.1007/s10295-010-0690-0. Epub 2010 Feb 2.
• 18. Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves.
  Luo J, Tian C, Xu J, Sun Y.J Enzyme Inhib Med Chem. 2009 Dec;24(6):1280-7. doi: 10.3109/14756360902829741.
• 19. A protein-bound polysaccharide from the stem bark of Eucommia ulmoides and its anti-complementary effect.
  Zhu H, Di H, Zhang Y, Zhang J, Chen D.Carbohydr Res. 2009 Jul 27;344(11):1319-24. doi: 10.1016/j.carres.2009.05.001. Epub 2009 May 8.
• 20. Extraction of aucubin from seeds of Eucommia ulmoides Oliv. using supercritical carbon dioxide.
  Li H, Hu J, Ouyang H, Li Y, Shi H, Ma C, Zhang Y.J AOAC Int. 2009 Jan-Feb;92(1):103-10.

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