Best Herbal Extracts

Botanical Ingredient

Cytisine

Cytisine is extracted from Thermopsis lanceolata. Stanford Chemicals has been providing quality Cytisine and many other natural plant extract for over 25 years.

SKU HE2921 Category

Cytisine Safety Tips

Handling of Cytisine should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

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    Ma L, Song F, Liu Z, Liu S.Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. doi: 10.1002/rcm.6424.
  • 2. Molecular Determinants of Subtype-Selective Efficacies of Cytisine and the Novel Compound NS3861 at Heteromeric Nicotinic Acetylcholine Receptors.
    Harpsoe K, Hald H, Timmermann DB, Jensen ML, Dyhring T, Nielsen EO, Peters D, Balle T, Gajhede M, Kastrup JS, Ahring PK.J Biol Chem. 2012 Dec 10. [Epub ahead of print]
  • 3. Nicotine receptor partial agonists for smoking cessation.
    Cahill K, Stead LF, Lancaster T, Polonio IB.Sao Paulo Med J. 2012;130(5):346-7.
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    Pichika R, Kuruvilla SA, Patel N, Vu K, Sinha S, Easwaramoorthy B, Narayanan TK, Shi B, Christian B, Mukherjee J.Nucl Med Biol. 2013 Jan;40(1):117-25. doi: 10.1016/j.nucmedbio.2012.09.009. Epub 2012 Nov 7.
  • 5. Synthesis and evaluation of 3-(123)I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic α4β2 receptor imaging agent.
    Pandey SK, Pan S, Kant R, Kuruvilla SA, Pan ML, Mukherjee J.Bioorg Med Chem Lett. 2012 Dec 15;22(24):7610-4. doi: 10.1016/j.bmcl.2012.10.012. Epub 2012 Oct 10.
  • 6. Modulation of α7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-β Interactions in Alzheimer’s Disease Brain.
    Ni R, Marutle A, Nordberg A.J Alzheimers Dis. 2012 Oct 5. [Epub ahead of print]
  • 7. Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors.
    Li YJ, Yang Q, Zhang K, Guo YY, Li XB, Yang L, Zhao MG, Wu YM.Neurotoxicology. 2012 Sep 26. doi:pii: S0161-813X(12)00221-5.  10.1016/j.neuro.2012.09.009. [Epub ahead of print]
  • 8. Quantitative changes of nicotinic receptors in the hippocampus of dystrophin-deficient mice.
    Ghedini PC, Avellar MC, De Lima TC, Lima-Landman MT, Lapa AJ, Souccar C.Brain Res. 2012 Nov 5;1483:96-104. doi: 10.1016/j.brainres.2012.09.021. Epub 2012 Sep 17.
  • 9. Quinolizidine alkaloids from Sophora velutina subsp. zimbabweensis (Fabaceae: Sophoreae).
    Korir E, Kiplimo JJ, Crouch NR, Moodley N, Koorbanally NA.Nat Prod Commun. 2012 Aug;7(8):999-1003.
  • 10. CC4, a dimer of cytisine, is a selective partial agonist at α4β2 / α6β2 nAChR with improved selectivity for tobacco smoking cessation.
    Sala M, Braida D, Pucci L, Manfredi I, Marks MJ, Wageman CR, Grady SR, Loi B, Fucile S, Fasoli F, Zoli M, Tasso B, Sparatore F, Clementi F, Gotti C.Br J Pharmacol. 2012 Sep 7. doi: 10.1111/j.1476-5381.2012.02204.x. [Epub ahead of print]
  • 11. Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2.
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  • 12. Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol  consumption in C57BL/6J mice.
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  • 13. Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.
    Tavares Xda S, Blum AP, Nakamura DT, Puskar NL, Shanata JA, Lester HA, Dougherty DA.J Am Chem Soc. 2012 Jul 18;134(28):11474-80. doi: 10.1021/ja3011379. Epub 2012 Jul 9.
  • 14. Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.
    Richards CI, Luong K, Srinivasan R, Turner SW, Dougherty DA, Korlach J, Lester HA.Nano Lett. 2012 Jul 11;12(7):3690-4. doi: 10.1021/nl301480h. Epub 2012 Jun 8.
  • 15. The nicotinic acetylcholine receptor as a target for antidepressant drug development.
    Philip NS, Carpenter LL, Tyrka AR, Price LH.ScientificWorldJournal. 2012;2012:104105. doi: 10.1100/2012/104105. Epub 2012 Apr 24. Review.
  • 16. Comparative analysis of quinolizidine alkaloids from different parts of Sophora alopecuroides seeds by UPLC-MS/MS.
    Wang H, Guo S, Qian D, Qian Y, Duan JA.J Pharm Biomed Anal. 2012 Aug-Sep;67-68:16-21. doi: 10.1016/j.jpba.2012.04.024. Epub 2012 Apr 25.
  • 17. Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.
    Stokes C, Papke RL.Neuropharmacology. 2012 Sep;63(4):538-46. doi: 10.1016/j.neuropharm.2012.04.035. Epub 2012 May 11.
  • 18. The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study.
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Details

Product Name

Cytisine

CAS No.

485-35-8

Molecular Formula

C11H14N2O

Molecular Weight

190.24

Botanical Source

Thermopsis lanceolata

Purity

99% HPLC

Appearance

White powder to yellow powder

Package

25 kg/drum

Storage

Stored in cool & dry places, protected from direct sunlight and heat.

Shelf Life

2 years









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