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Citrus Extract Limonin


98% Limonin HPLC; 4-90% Synepherin HPLC; Isoflavone 30% HPLC

Botanical Source:

Citrus Limonin


25 kg/drum


Stored in cool & dry places, protected from direct sunlight and heat.

SKU HE3371 Category

Citrus Extract Limonin Safety Tips

Handling of Citrus Extract Limonin should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.


  • 1. Protective effects of natsumikan (Citrus natsudaidai) extract on acetaminophen-induced lethal hepatotoxicity in mice.
    Yamaura K, Nakayama N, Shimada M, Ueno K.Pharmacognosy Res. 2012 Oct;4(4):234-6. doi: 10.4103/0974-8490.102274.
  • 2. Green synthesis of gold nanoparticles using Citrus fruits (Citrus limon, Citrus reticulata and Citrus sinensis) aqueous extract and its characterization.
    Sujitha MV, Kannan S.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep 28;102C:15-23. doi: 10.1016/j.saa.2012.09.042. [Epub ahead of print]
  • 3. Antioxidant activity and effective compounds of immature calamondin peel.
    Yu MW, Lou SN, Chiu EM, Ho CT.Food Chem. 2013 Feb 15;136(3-4):1130-5. doi: 10.1016/j.foodchem.2012.09.088. Epub 2012 Oct 2.
  • 4. Citrus peel polymethoxylated flavones extract modulates liver and heart function parameters in diet induced hypercholesterolemic rats.
    Green CO, Wheatley AO, McGrowder DA, Dilworth LL, Asemota HN.Food Chem Toxicol. 2012 Oct 23;51C:306-309. doi: 10.1016/j.fct.2012.10.005. [Epub ahead of print]
  • 5. Use of Moroccan medicinal plant extracts as botanical fungicide against citrus blue mould.
    Askarne L, Talibi I, Boubaker H, Boudyach EH, Msanda F, Saadi B, Ait Ben Aoumar A.Lett Appl Microbiol. 2013 Jan;56(1):37-43. doi: 10.1111/lam.12012. Epub 2012 Nov 15.
  • 6. Assessing the efficacy of citrus aurantifolia extract on smear layer removal with scanning electron microscope.
    Bolhari B, Sharifian MR, Aminsobhani M, Monsef Esfehani HR, Tavakolian P.Iran Endod J. 2012 Spring;7(2):88-97. Epub 2012 Jun 1.
  • 7. Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes.
    Ihara H, Yamamoto H, Ida T, Tsutsuki H, Sakamoto T, Fujita T, Okada T, Kozaki S.Biosci Biotechnol Biochem. 2012;76(10):1843-8. Epub 2012 Oct 7.
  • 8. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.
    Sandoval-Montemayor NE, García A, Elizondo-Treviño E, Garza-González E, Alvarez L, del Rayo Camacho-Corona M.Molecules. 2012 Sep 19;17(9):11173-84.
  • 9. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine.
    Stohs SJ, Preuss HG, Shara M.Int J Med Sci. 2012;9(7):527-38. Epub 2012 Aug 29.
  • 10. Oxidative stress-related lung dysfunction by chromium(VI): alleviation by Citrus aurantium L.
    Soudani N, Rafrafi M, Ben Amara I, Hakim A, Troudi A, Zeghal KM, Ben Salah H, Boudawara T, Zeghal N.J Physiol Biochem. 2012 Sep 13. [Epub ahead of print]
  • 11. HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of  Citrus aurantium  L. var. amara Peel with Antiedematogenic Activity.
    Mencherini T, Campone L, Piccinelli AL, García Mesa M, Sánchez DM, Aquino RP, Rastrelli L.J Agric Food Chem. 2012 Sep 17. [Epub ahead of print]
  • 12. Characterization of polymethoxylated flavonoids (PMFs) in the peels of ‘Shatangju’ mandarin ( Citrus reticulata Blanco) by online high-performance liquid chromatography coupled to photodiode array detection and electrospray tandem mass spectrometry.
    Zhang JY, Zhang Q, Zhang HX, Ma Q, Lu JQ, Qiao YJ.J Agric Food Chem. 2012 Sep 12;60(36):9023-34. doi: 10.1021/jf302713c. Epub 2012 Sep 4.
  • 13. Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study.
    Cohen HA, Rozen J, Kristal H, Laks Y, Berkovitch M, Uziel Y, Kozer E, Pomeranz A, Efrat H.Pediatrics. 2012 Sep;130(3):465-71. doi: 10.1542/peds.2011-3075. Epub 2012 Aug 6.
  • 14. Potential of Moringa oleifera root and Citrus sinensis fruit rind extracts in the treatment of ulcerative colitis in mice.
    Gholap PA, Nirmal SA, Pattan SR, Pal SC, Mandal SC.Pharm Biol. 2012 Oct;50(10):1297-302. doi: 10.3109/13880209.2012.674142. Epub 2012 Jul 31.
  • 15. Dietary polyphenols and mechanisms of osteoarthritis.
    Shen CL, Smith BJ, Lo DF, Chyu MC, Dunn DM, Chen CH, Kwun IS.J Nutr Biochem. 2012 Nov;23(11):1367-77. doi: 10.1016/j.jnutbio.2012.04.001. Epub 2012 Jul 23.
  • 16. Antimicrobial assays of natural extracts and their inhibitory effect against Listeria innocua and fish spoilage bacteria, after incorporation into biopolymer edible films.
    Iturriaga L, Olabarrieta I, de Marañón IM.Int J Food Microbiol. 2012 Aug 1;158(1):58-64. doi: 10.1016/j.ijfoodmicro.2012.07.001. Epub 2012 Jul 11.
  • 17. Larvicidal, pupicidal, repellent and adulticidal activity of Citrus sinensis orange peel extract against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae).
    Murugan K, Mahesh Kumar P, Kovendan K, Amerasan D, Subrmaniam J, Hwang JS.Parasitol Res. 2012 Oct;111(4):1757-69. Epub 2012 Jul 15.
  • 18. Neurotrophic effect of citrus auraptene: neuritogenic activity in PC12 cells.
    Furukawa Y, Watanabe S, Okuyama S, Nakajima M.Int J Mol Sci. 2012;13(5):5338-47. doi: 10.3390/ijms13055338. Epub 2012 Apr 27.
  • 19. Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice.
    Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, Choi MS.J Nutr Biochem. 2012 Jun 11. [Epub ahead of print]
  • 20. Mild Mitochondrial Depolarization is Involved in a Neuroprotective Mechanism of Citrus sunki Peel Extract.
    Wu JJ, Cui Y, Yang YS, Jung SC, Hyun JW, Maeng YH, Park DB, Lee SR, Kim SJ, Eun SY.Phytother Res. 2012 Jun 8. doi: 10.1002/ptr.4745. [Epub ahead of print]




98% Limonin HPLC; 4-90% Synepherin HPLC; Isoflavone 30% HPLC

Botanical Source

Citrus Limonin


25 kg/drum


Stored in cool & dry places, protected from direct sunlight and heat.


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